CONFERENCE SCHEDULE April 16 - 20, 2018



MONDAY, April 16th

9:30 – 11:00 am REGISTRATION

10:50 – 11:00 am WELCOME & OPENING REMARKS

Blanche Capel

11:00 – 11:30 am KEYNOTE LECTURE

Serge Nef Sex determination at the single cell level

Transcription and Signaling

11:30 – 11:45 am Christoph Englert Gdf6Y is a novel sex-determining gene in the short-lived African killifish Nothobranchius furzeri

11:45 – 12:00 pm Francis Poulat Role of Trim28 in supporting cell fate


2:00 – 2:30 pm Yann Guiguen Genome-wide approaches to elucidate evolution of sex determination systems and sex determining genes in fish

2:30 – 2:45 pm Minghui Li Role and molecular mechanism of amhy in tilapia sex determination

2:45 – 3:00 pm Simon Windley The role of Nedd4 in mammalian sex determination and gonad development

3:00 – 3:15 pm Josephine Bowles Retinoic acid antagonises testis development in mice

3:15 – 3:30 pm Miki Inoue Ad4BP/SF-1 regulates differentiation and metabolic activation in fetal Leydig cells


4:00 – 4:30 pm Phillip Newmark* Germ cell development and regeneration in planarians
*International Society of Differentiation – Sponsored Speaker

4:30 – 4:45 pm Kellee Siegfried Dmrt1 is necessary for male sexual development in zebrafish

4:45 – 5:00 pm Catherine Bélanger Characterization of mouse models of CHARGE syndrome suggests a key role for co-transcriptional alternative splicing in male sex determination

5:00 – 5:15 pm Michael Weiss Human sex determination at the edge of ambiguity: Impaired SRY phosphorylation attenuates expression of the male program

5:15 – 5:30 pm Susan Taymans State of the Science: NIH’s support for the field of sex determination and differences/disorders in sex development

6:30 – 10:00 pm WELCOME RECEPTION



TUESDAY, April 17th

7:30 – 8:30 am REGISTRATION


Differentiation and Organogenesis

8:30 – 9:00 am Juli Wade Sculpting reproductive circuits: Relationships among hormones, morphology, and behavior in male and female anole lizards

9:00 – 9:15 am Jane Fenelon The egg, embryo and hatchling echidna: Differentiation of the gonads and external genitalia

9:15 – 9:30 am Kentaro Suzuki Establishment of the genital tubercle (GT) slice culture system to study the mechanism of androgen-driven embryonic urethral masculinization

9:30 – 9:45 am Bonnie Kircher Growing apart: Characterizing the development of sexual dimorphism

9:45 – 10:00 am Tony DeFalco Testicular vasculature is a critical component of the fetal Leydig stem cell niche


10:30 – 10:45 am Barry Hinton Phosphatase and tensin homologue (Pten) is essential for Wolffian/epididymal postnatal development and male fertility

10:45 – 11:00 am Takashi Koyama Revisiting the steroid theory of sex inducer; Trans-species SNP in a steroidogenic enzyme, HSD17B1, is associated with sex in Seriola species

11:00 – 11:15 am Ajay Pradham Zebrafish sex differentiation: Interactions between gonads and brain

11:15 – 11:30 am Eric Pailhoux Estrogens are key ovarian differentiating hormones in rabbits

11:30 – 11:45 am Aleisha Symon Unravelling the role of SOX9 target genes in mammalian sex determination using NT2/D1 cells

11:45 – 12:00 pm Jennifer McKey Innervation of developing mouse gonads is sexually dimorphic


Epigenetics and Genomic Approaches

2:00 – 2:30 pm Silvana Guioli Chicken ovary differentiation; Insights from embryology and genetic studies

2:30 – 2:45 pm Sara Garcia-Moreno Epigenetic regulation of sex determination in the mouse fetal gonad

2:45 – 3:00 pm Timothy Hore Surveying epigenetic sex determination in vertebrates

3:00 – 3:15 pm Benjamin Parrott A means to adapt, a means to disrupt: Epigenome-by-environment dynamics underlying sex determination and reproductive perturbations in the American alligator

3:15 – 3:30 pm Jennifer Schmahl Male to female sex reversal through Y chr silencing


4:00 – 4:15 pm Tasman Daish Analysis of novel sex biased long non-coding RNA candidates in egg laying mammals

4:15 – 4:30 pm You-Jiun Pan The transcriptome analysis of premeiotic germ cells in zebrafish

4:30 – 4:45 pm Jessica Maxfield Restructuring the gonad: Do two closely related fish species do it the same way?

4:45 – 5:00 pm Astrid Böhne   Re-occurrence, common ancestry and novelty: Sex chromosome evolution in cichlid fishes

5:00 – 5:15 pm Humphrey H-C Yao Cross-platform integration of single-cell RNA-seq technologies reveals novel transcriptional signatures for cell populations in murine embryonic testes

5:15 – 5:30 pm John Postlethwait Single cell transcriptomics of transitional gonads in zebrafish sex determination



WEDNESDAY, April 18th


Environmental Effects on Sex Development and Fertility

8:30 – 9:00 am Matthew Grober Sexual plasticity in teleost fishes

9:00 – 9:15 am Yoji Yamamoto Temperature-dependent sex determination in wild cobaltcap silverside Hypoantherina tsurugae, an atherinid fish from the northwest Pacific ocean

9:15 – 9:30 am Jean-François Baroiller Tilapia sex determination: Where temperature and/or minor genetic factors commonly override sex chromosomes

9:30 – 9:45 am Chutian Ge The histone demethylase KMD6B regulates temperature-dependent sex determination in a turtle species

9:45 – 10:00 am Clare Holleley A unified model for the molecular basis and evolution of temperature-dependent sex determination


10:30 – 10:45 am Ngoc Mai Nguyen Atrazine induces same-sex copulatory behavior in exposed male Xenopus laevis

10:45 – 11:00 am Marilyn Renfree Coding and non-coding RNAs in the phallus are affected by androgen- and oestrogen-induced sex-reversal in a marsupial

11:00 – 11:15 am Tegan Horan Environmental effects on spermatogenesis

11:15 – 11:30 am Andrew Pask Estrogen blocks the nuclear translocation of SOX9 in the mouse gonad and human NT2/D1 cell line

11:30 – 11:45 am Erica Todd Sex switching in labrid fishes involves stress, novel sex genes and developmental regression through a pluripotent-like state

11:45 – 12:00 pm Boudjema Imarazene Micro-evolution of sex determination mechanisms and sex determining genes in the cavefish, Astyanax mexicanus


6:00 – 10:00 pm POSTER SESSION*
*Sponsored by International Society of Differentiation



THURSDAY, April 19th


Sex Chromosomes & Evolution

8:30 – 9:00 am Asato Kuroiwa Sex chromosome evolution and sex-determining mechanism in Sry-absent XO/XO mammals, genus Tokudaia

9:00 – 9:15 am Marko Horb Developmental systems drift of sex determination in frogs

9:15 – 9:30 am Daniel Jeffries Convergent recruitment of chromosomes for sex determination via an unprecedented rate of turnover in true frogs

9:30 – 9:45 am Lukas Kratochvil The rise, stability and fall of differentiated sex chromosomes in reptiles

9:45 – 10:00 am Stuart Nielsen Dynamic sex chromosomes in Old World chameleons (Squamata: Chamaeleonidae)


10:30 – 10:45 am Michael Rovatsos Evolution of sex chromosomes in amniotes: Shared ancestry or co-option?

10:45 – 11:00 am Helena D’Cotta Diversity of Nile tilapia Y chromosomes: A population study

11:00 – 11:15 am Craig Smith Gonadal and endocrine analysis of a gynandromorphic chicken

11:15 – 11:30 am Barret Phillips Lineage-specific X-Y differentiation in the common frog

11:30 – 11:45 am Ming Wen Sex determination in the goldfish, Carassius auratus

11:45 – 12:00 pm Egle Ortega XO males with limited Y chromosome genes display incomplete fetal gonadal masculinization


Germ Cells and Soma

2:00 – 2:30 pm Patrick Western Epigenetic regulation in the germline: Setting a foundation for the next generation

2:30 – 2:45 pm Mateus Adolfi Retinoic acid regulates expression of genes related to sex determination in medaka

2:45 – 3:00 pm Kei-ichiro Ishiguro Identification of a novel nuclear factor for initiation of meiosis

3:00 – 3:15 pm Yoshiakira Kanai High-FGF9/low-retinoic acid signaling states in Sertoli valve niche for spermatogenic stem/progenitor cells

3:15 – 3:30 pm Kenichi Kashimada Enforced expression of Nr5a1 in mouse fetal ovaries causes premature ovarian insufficiency by dysregulating Notch signaling


4:00 – 4:15 pm Anqi Fu Dynamic expression profiles of Irx3 and Irx5 during germline cyst breakdown and primordial follicle formation promote follicle integrity and female fertility in mice

4:15 – 4:30 pm Yan-Wei Wang Investigation of foxl3 expression and function in the zebrafish gonads

4:30 – 4:45 pm Amaury Herpin Sox5 is involved in germ cell regulation and sex determination in medaka following co-option of nested transposable elements

4:45 – 5:00 pm Oscar Ortega-Recalde Erasure of epigenetic memory in the germline of female zebrafish

5:00 – 5:15 pm Michael O’Neill Role of Xlr3 in gametogenesis and behavior in mice

7:00 – 10:00 pm CONFERENCE DINNER



FRIDAY, April 20th


Disorders of Sex Development

8:30 – 9:00 am Ken McElreavey New genetic factors involved in human sex determination

9:00 – 9:15 am Robin Lovell-Badge The regulation of Sox9 during sex determination in the mouse

9:15 – 9:30 am Andrew Sinclair Duplication and deletion of key SOX9 enhancers cause sex reversal in humans

9:30 – 10:00 am Vincent Harley Role of SRY in attention-deficit hyperactivity disorder and Parkinson’s disease


10:30 – 10:45 am Katie Ayers Next generation sequencing of a large international cohort of patients with disorders of sex development reveals diagnostic and novel genetic variants

10:45 – 11:00 am Stefan Bagheri-Fam Mutations in HMGCS2 are associated with disorders of sex development

11:00 – 11:15 am Harry Ostrer How mutations in signal transduction pathways can cause 46,XY gonadal dysgenesis

11:15 – 11:30 am Andy Greenfield Mouse models of human disorders of sex development

11:30 – 11:45 am CLOSING REMARKS

Marty Cohn