MONDAY, April 13th


9:30 – 11:00 am REGISTRATION

10:50 – 11:00 am OPENING REMARKS: Richard Behringer

11:00 – 11:30 am KEYNOTE LECTURE

Martin Cohn Development of external genitalia: from evolutionary origins to congenital malformations


Sex Chromosomes, Genetics, and Genomics

11:30 – 12:00 pm John Postlewaite Wild sex in zebrafish

12:00 – 12:15 pm Qiaowei Pan Identification of the master sex determining gene in Northern pike (Esox lucius, Esociformes, teleosts) and its evolution within Esociformes

12:15 – 12:30 pm Luke Lambeth Aromatase over-expression in transgenic chickens causes male-to-female sex reversal



2:15 – 2:45 pm Frank Grutzner Platypus global meiotic silencing shows recent origin of MSCI in therian mammals 

2:45 – 3:00 pm Tony Gamble Identifying sex-specific markers and sex chromosome systems with RAD-seq

3:00 – 3:15 pm Kazumi Matsubara In search of a reptile sex determining gene

3:15 – 3:30 pm Paul Saunders A new sex determination system in a mammal, the African pygmy mouse Mus minuoides. How did it evolve?



3:45 – 4:15 pm Martin Beye What can honeybees tell us about the regulation and evolution of sex determination?

4:15 – 4:30 pm Sylvain Bertho How does, SdY, the unusual master sex determining factor of salmonids, trigger testicular differentiation?

4:30 – 4:45 pm Songlin Chen Whole-genome sequence of half-smooth tongue sole (Cynoglossus semilaevis) reveals the evolution of ZW sex chromosomes and the mechanism for sex determination and sex reversal

4:45 – 5:00 pm Michael White Sequencing the threespine stickleback Y chromosome: A vertebrate model system for sex chromosome evolution

5:00 – 5:15 pm Reade Roberts Polygenic sex determination in the cichlid fish Astatotilapia burtoni

5:15 – 5:30 pm Nicole Valenzuela Sex determination and the birth and death of reptile species

6:30 – 10:00 pm WELCOME RECEPTION


TUESDAY, April 14th


7:30 – 8:00 am REGISTRATION


Sex Determination/Transcriptional Regulation

8:30 – 9:00 am David Zarkower Dmrt1 and gonadal cell fate regulation, from genomic to atomic scale

9:00 – 9:15 am Yoshiakira Kanai Identification of the Sry-dependent and –independent molecular pathways in mouse testiculogenesis

9:15 – 9:30 am Dimuthi Alankarage Unraveling embryonic testicular pathways via Sox9 KO RNA-Seq and SOX9 ChIP-Seq

9:30 – 9:45 am Francis Poulat Conserved genomic signature defines fetal Sertoli cell fate in mammals

9:45 – 10:00 am Gwenn-Aël Carré Studying the role of CBP in mouse sex determination




10:15 – 10:45 am Eric Pailloux Genetic cascade of sex determination in goats

10:45 – 11:00 am Robin Lovell-Badge Deleting TESCO, the testis-specific enhancer of Sox9, does not cause sex reversal

11:00 – 11:15 am Liang Zhao Functional degradation of both Sry and the Sox9 enhancer TESCO underpins the atypical sex determination system in Mus minutoides

11:15 – 11:30 am Thomas Ohnesorg Identification and analysis of two novel enhancers of human SOX9: Implications for disorders of sex development (DSD)

11:30 – 11:45 am Yuichi Shima Functional importance of fetal Leydig cells in postnatal testis development

11:45 – 12:00 pm Deepak Modi LIM-HD transcriptional factor LHX2 specifies ovarian fate and represses testicular fate in mouse gonads




Sex Determination/Differentiation

1:45 – 2:15 pm Dagmar Wilhelm New regulators of mammalian sex determination and gonad development

2:15 – 2:30 pm Yusuke Takehana Co-option of Sox3 as the sex-determining factor in a medaka fish Oryzias dancena

2:30 – 2:45 pm Madeleine Pope Map3k4 is a dose-dependent modifier of sensitivity to B6-YPOS gonadal sex reversal

2:45 – 3:00 pm Joan Jorgensen Hedgehog regulated transcription factor GLI3 is essential for normal fetal Leydig cell maturation and testis descent

3:00 – 3:15 pm Tuck Ngun Epigenome-wide association study of sexual orientation in monozygotic twins


3:35 – 4:05 pm KEYNOTE LECTURE

Jenny Marshall Graves Sex and speciation: Did the evolution of SRY trigger mammalian divergence?


4:05 – 4:20 pm Barbara Nicol The transcription factor RUNX1 is a new regulator for the maintenance of ovarian identity

4:20 – 4:35 pm Robin Lindeman Sexual cell fate reprogramming in the ovary by Dmrt1

4:35 – 4:50 pm Rachel Mullen Mesenchyme-epithelia signaling during reproductive tract development

4:50 – 5:05 pm Chen-wei Hsu Sexually dimorphic gene expression during early zebrafish gonadal development

5:05 – 5:20 pm Takuto Imai Gsdf is required for the testicular development during early gonadal differentiation period in medaka



WEDNESDAY, April 15th




Environmental Effects on Sex Determination, Differentiation and Fertility

8:30 – 9:00 am Carlos Strussmann Environmental effects on sex determination and fertility of fish, with special reference to temperature and Atheriniforms

9:00 – 9:15 am Yoji Yamamoto Genetic sex determination at intermediate temperatures in perjerry Odontesthes bonariensis, a fish with marked temperature-dependent sex determination

9:15 – 9:30 am Arthur Georges Sex reversal triggers rapid evolution of temperature dependent sex determination

9:30 – 9:45 am Robert Literman Temperature-dependent regulation of sex determining genes in the painted turtle (Chrysemys picta)

9:45 – 10:00 am Blanche Capel Comparison of transcriptome-wide time course data sets between M. musculus and T. scripta reveals conservation and divergence in sex determination pathways

10:00 – 10:15 am Yuiko Matsumoto Gonadal aromatase (CYP19A1) expression is controlled through epigenetic mechanisms in species with temperature-dependent sex determination




10:35 – 11:05 am Masahisa Nakamura Are androgens and its receptor involved in sex determination in amphibians?

11:05 – 11:20 am Xuan Luong Differential E2 sensitivities among populations of Xenopus laevus

11:20 – 11:35 am Yu Chen EFNB2 and neighboring LncRNAs during early phallus development in a marsupial

11:35 – 11:50 am Per-Erik Olsson Involvement of steroid hormones, prostaglandins and retinoic acid in zebrafish sex differentiation and sexual behavior

11:50 – 12:05 am Hui Liu Plasticity of sex: A fish tale




6:00 – 10:00 pm POSTER SESSION


THURSDAY, April 16th





8:30 – 9:00 am Bruce Draper Oocyte-produced BMP15 maintains adult female sex in zebrafish

9:00 – 9:15 am Adam Luckenback Establishing the sex determination system and downstream events of gonadal sex differentiation in sablefish

9:15 – 9:30 am Manfred Schartl Regulation of primordial germ cell numbers and retinoic acid induction of meiosis at the sex determination stage

9:30 – 9:45 am Humphrey H-C Yao Autocrine/paracrine regulation of somatic cell fate in the fetal testis

9:45 – 10:00 am Tony DeFalco Macrophages and vasculature: An unlikely partnership driving fetal testis differentiation



10:20 – 10:35 am Barry Hinton Phosphatase and tensin homologue (Pten) is essential for Wolffian/epididymal postnatal development and male fertility

10:35 – 10:50 am Shou-Ting Yen Cell behaviors during Müllerian duct formation

10:50 – 11:05 am Katie Ayers DMRT1 is required for Müllerian duct formation in the chicken embryo




11:15 – 11:30 am Tiffany Phillips A comprehensive atlas of the adult mouse penis

11:30 – 11:45 am Marilyn Renfree Alternative splicing of HOX and their adjacent Lnc-RNAs may regulate male and female phallus development

11:45 – 12:00 pm Christine Larkins The role of androgen signaling in sexual differentiation of the urogenital sinus ridge




Disorders of Sex Development

2:00 – 2:30 pm Dolores J. Lamb Gene dosage changes affecting human genitourinary development

2:30 – 2:45 pm Eric Vilain Exome sequencing for the diagnosis of 46,XY disorders of sex development

2:45 – 3:00 pm Andrew Sinclair Exome sequencing identified a novel gene associated with disorders of sex development and intellectual disability

3:00 – 3:15 pm Stefan Bahgeri-Fam FGFR2C mutation in XY sex reversal with craniosysostosis

3:15 – 3:30 pm Arthur Arnold Sex differences in mouse models of disease caused by cell autonomous effects of X and Y genes




3:50 – 4:20 pm Anna Biason-Lauber Why boys will be boys and girls will be girls: human sex development and its disorders

4:20 – 4:35 pm Yun-Fai Chris Lau The sex-determining gene in health and diseases

4:35 – 4:50 pm Harry Ostrer Molecular phenotypes of variants in human sex-determining genes: Pathogenicity and population studies

4:50 – 5:05 pm Pascal Bernard Defining the role of long-non coding RNAs in the etiology of hypospadias

5:05 – 5:20 pm Peter Koopman Found in translation: Taking sex research to DSD patients, advocacy groups and clinicians


7:00 – 10:00 pm CONFERENCE DINNER



FRIDAY, April 17th



Sex Determination of the Germ Line and Soma Interactions

8:30 – 9:00 am Minoru Tanaka Germline sex determination in medaka

9:00 – 9:15 am Toshiya Nishimura A novel view on the structure of testes and ovaries

9:15 – 9:30 am Michihiko Ito Promoter evolution of Dmrt1: Its expression and function in germ stem cells and male somatic cells during vertebrate evolution

9:30 – 10:00 am Yumiko Saga The mechanism of sex determination of mouse germ cells




10:30 – 10:45 am Yukiko Yamazaki Dose-dependent functions of FGF9 in XY primordial germ cell differentiation

10:45 – 11:00 am Egle Ortega Sox9 overexpression can sufficiently supplement for a lack of Sry in terms of function in spermatogenesis and adult male fertility

11:00 – 11:15 am Guan-Chung Wu Oocytes directly regulate soma replacement from male to female in the protandrous black porgy, Acanthopagrus schlegeli

11:15 – 11:30 am Amaury Herpin A novel evolutionary conserved mechanism of RNA stability regulates drmt1bY expression in PGCs prior to the sex determination stage